Here we have a comprehensive list of variants in SCN5A found in individuals affected and unaffected with the two diseases most commonly associated with variants in SCN5A: Brugada Syndrome (BrS1; OMIM: 601144) and long QT type 3 (LQT3; OMIM: 603830). Coding variants are referenced to isoform Q14524-1 (ENST00000333535.9) to match convention. 'Total Carriers' is the number of heterozygotes diagnosed with LQT3, BrS1, Unaffected with disease, and found in the genome aggregation database (gnomAD). 'Other' is the number of heterozygoes diagnosed with a cardiac disease which is not LQT3 or BrS1. Click the variant link for more details. Functional classification of variants was done according to the following criteria for sodium channel peak tail current, stead state voltage of activation, and/or late/persistent current: Loss-of-function (LOF) < 10% peak, partial LOF <50% peak, mild LOF 50-75% peak, normal 75-125% peak, Gain-of-function (GOF) > 125% peak current or >300% late current, partial LOF >10 mV rightward shift in V0.5 activation. Structurally, a "Non_Hotspot" variant was surrounded by variants with <10% BrS1 penetrance on average, a "Mild_Hotspot" variant was surrounded by variants with between 10% and 40% BrS1 penetrance, on average, a "Hotspot" variant was surrounded by variants with greater than 40% BrS1 penetrance, on average.